Effects of 3-Glucosaminoglycan Sulfate on Hemorheologic Parameters in Hyperlipidemic Peripheral Vascular Disease (PVD) Patients

Abstract

The effects of 3-glucosaminoglycan sulfate on lipids and the hemorheologic parameters were observed in a preliminary double-blind crossover study in 30 hyperlipidemic peripheral vascular disease (PVD) patients. Parenteral adminis tration of the test drug was associated with a reduction in serum lipids, espe cially in triglyceride levels, and a lowering of fibrinogen, plasma viscosity, and whole blood viscosity levels. These effects justify the drug's use in the treatment of PVD, especially when associated with hypertriglyceridemia and hemorheo logic disturbances.