Unintentional Injury Death Among Solid Organ Transplant Recipients: Trends and Risk Factors

Author:

Serpico Scott1ORCID,Manikath James Rosy2,Koizumi Naoru2,Ortiz Jorge3

Affiliation:

1. Department of Clinical Research, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA

2. School of Public Policy and Gov’t, George Mason University, Arlington, TX, USA

3. Department of Transplantation and Surgery, Erie County Medical Center, Buffalo, NY, USA

Abstract

Unintentional injury death (UID) is a leading cause of mortality worldwide, and individuals with chronic diseases are at higher risk. Though organ transplant can improve the lives of those with chronic disease, these individuals remain in suboptimal physical and mental health after surgery that predisposes them to UID. To quantify the scale of UID among solid organ transplant recipients, we performed a retrospective analysis using United Network of Organ Sharing data from adults who underwent kidney, liver or pancreas transplant between 2000-2021. Our study aimed to identify risk factors for UID in this cohort by comparing basic patient, donor, and transplant characteristics of the groups (UID or all other cause death). The largest proportion of UID was seen in the kidney group (.8%), followed by liver (.7%) and then pancreas (.3%). Male sex was the most significant risk factor among kidney and liver recipients. Whites had a higher risk for UID relative to their non-White counterparts in the kidney and liver groups. In both groups, advancing age conferred a protective effect, whereas higher functional status was a risk factor. Our findings shed new light on a significant source of mortality within the transplant population.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Reference13 articles.

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