Circadian Variation of the Efficacy of Thrombolytic Therapy in Acute Myocardial Infarction—Isn’t the Time Ripe for Cardiovascular Chronotherapy?-Reference-Cited by-同舟云学术

Circadian Variation of the Efficacy of Thrombolytic Therapy in Acute Myocardial Infarction—Isn’t the Time Ripe for Cardiovascular Chronotherapy?

Published:2004-05 Issue:3 Volume:55 Page:257-263
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Reisin Leonardo H.¹,Pancheva Nadya²,Berman Michael²,Khalameizer Vladimir²,Jafary Jamal²,Yosefy Chaim²,Blaer Yosef²,Manevich Ilia²,Peled Ronit³,Scharf Shimon²

Affiliation:

1. Cardiology Department, Barzilai Medical Center Campus, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel,

2. Cardiology Department, Barzilai Medical Center Campus, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel

3. Epidemiology Research Institute, Barzilai Medical Center Campus, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel

Abstract

This study was designed to assess the circadian variation of the efficacy of thrombolytic therapy (TT) in 163 patients with acute myocardial infarction. Statistical analysis of the results suggests the existence of circadian variation in the efficacy of thrombolytic therapy with marked early morning resistance and significantly better late daytime results. There is a strong relationship between the normal physiologic rhythms of biochemical, hemodynamic, and hematologic parameters, observed in patients with CAD and the circadian fluctuations of efficacy of TT. Obviously the efficacy of TT is influenced by more evident impact of chronorisk factors during the early morning hours.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000331970405500304

Reference20 articles.

1. Circadian variations of onset of acute myocardial infarction and efficacy of thrombolytic therapy

2. Meta-Analysis of the Morning Excess of Acute Myocardial Infarction and Sudden Cardiac Death

3. Gender differences in triggering of acute myocardial infarction

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