Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication-Reference-Cited by-同舟云学术

Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

Published:2013-05-21 Issue:6 Volume:65 Page:491-496
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Gardner Andrew W.¹²,Parker Donald E.³,Montgomery Polly S.¹,Blevins Steve M.⁴,Teague April M.⁵,Casanegra Ana I.⁶

Affiliation:

1. Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

2. Veterans Affairs Medical Center, Oklahoma City, OK, USA

3. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

4. General Internal Medicine Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

5. CMRI Diabetes and Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

6. Cardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Abstract

We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides ( P < .001), total daily ambulatory time ( P < .01), peak activity index ( P < .01), daily average cadence ( P < .05), and the maximum cadences for 60 minutes ( P < .05), 30 minutes ( P < .05), 20 minutes ( P < .05), and 5 minutes ( P < .01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures ( P > .05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319713489769

Reference29 articles.

1. ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic)

2. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

3. Review of mortality and cardiovascular event rates in patients enrolled in clinical trials for claudication therapies

4. Mortality over a Period of 10 Years in Patients with Peripheral Arterial Disease

5. Progressive vs single-stage treadmill tests for evaluation of claudication

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease;npj Aging;2024-04-05

2. Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review;International Journal of Molecular Sciences;2024-01-23

3. Benefits of Integrating Technology into Home Exercise Therapy in Patients with Lower Extremity Peripheral Artery Disease;Journal of Clinical Medicine;2023-12-12

4. Effects of Long‐Term Home Exercise in Participants With Peripheral Artery Disease;Journal of the American Heart Association;2023-11-07

5. Near-Infrared Spectroscopy Used to Assess Physiological Muscle Adaptations in Exercise Clinical Trials: A Systematic Review;Biology;2022-07-19