Elevated Levels of Adhesion Proteins Are Associated With Low Ankle–Brachial Index-Reference-Cited by-同舟云学术

Elevated Levels of Adhesion Proteins Are Associated With Low Ankle–Brachial Index

Published:2016-07-20 Issue:4 Volume:68 Page:322-329
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Berardi Cecilia¹²,Wassel Christine L.³,Decker Paul A.²,Larson Nicholas B.²,Kirsch Phillip S.²,Andrade Mariza de²,Tsai Michael Y.⁴,Pankow James S.⁵,Sale Michele M.⁶,Sicotte Hugues²,Tang Weihong⁵,Hanson Naomi Q.⁴,McDermott Mary M.⁷,Criqui Michael H.⁸,Allison Michael A.⁸,Bielinski Suzette J.²

Affiliation:

1. Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA

2. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

3. Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, VT, USA

4. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

5. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA

6. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA

7. Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

8. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA

Abstract

Inflammation plays a pivotal role in peripheral artery disease (PAD). Cellular adhesion proteins mediate the interaction of leukocytes with endothelial cells during inflammation. To determine the association of cellular adhesion molecules with ankle–brachial index (ABI) and ABI category (≤1.0 vs >1.0) in a diverse population, 15 adhesion proteins were measured in the Multi-Ethnic Study of Atherosclerosis (MESA). To assess multivariable associations of each protein with ABI and ABI category, linear and logistic regression was used, respectively. Among 2364 participants, 23 presented with poorly compressible arteries (ABI > 1.4) and were excluded and 261 had ABI ≤ 1.0. Adjusting for traditional risk factors, elevated levels of soluble P-selectin, hepatocyte growth factor, and secretory leukocyte protease inhibitor were associated with lower ABI ( P = .0004, .001, and .002, respectively). Per each standard deviation of protein, we found 26%, 20%, and 19% greater odds of lower ABI category ( P = .001, .01, and .02, respectively). Further investigation into the adhesion pathway may shed new light on biological mechanisms implicated in PAD.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319716659178

Reference50 articles.

1. Heart Disease and Stroke Statistics—2013 Update

2. Ankle Brachial Index Combined With Framingham Risk Score to Predict Cardiovascular Events and Mortality

3. The Ankle-Brachial Index and Incident Cardiovascular Events in the MESA (Multi-Ethnic Study of Atherosclerosis)

4. Ankle-Brachial Index and Subclinical Cardiac and Carotid Disease

5. Coronary Artery Disease in Peripheral Vascular Patients

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