Predictors of Symptom Development in Intermediate Carotid Artery Stenosis

Author:

Koklu Erkan1,Yuksel Isa Oner1,Arslan Sakir1,Cagirci Goksel1,Gencer Elif Sarionder2,Koc Pinar3,Cay Serkan4,Kizilirmak Filiz5,Esin Murat1

Affiliation:

1. Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey

2. Neurology Clinic, Antalya Training and Research Hospital, Antalya, Turkey

3. Radiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey

4. Cardiology Clinic, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey

5. Department of Cardiology, Medipol University Faculty of Medicine, Istanbul, Turkey

Abstract

Platelets play an important role in the pathogenesis of atherothrombosis. Platelet activation is associated with increased mean platelet volume (MPV) and platelet distribution width (PDW). In this study, we investigated the relation of MPV and PDW with the risk of stroke in patients with intermediate (50%-70%) carotid artery stenosis. A total of 254 patients (115 symptomatic and 139 asymptomatic) with intermediate carotid artery stenosis were enrolled in this study. Symptomatic and asymptomatic patients were compared in regard to MPV and PDW. Mean platelet volume was significantly greater in the symptomatic group compared with the asymptomatic group (11.1 and 9.4 fL, respectively; P < .001). Platelet distribution width was significantly greater in the symptomatic group compared with the asymptomatic group (15.0% and 11.9%, respectively; P < .001). Multivariate regression analysis showed that an MPV ≥10.2 fL and a PDW ≥14.3% were independent predictors of developing symptomatic carotid artery stenosis. Mean platelet volume and PDW are increased in the presence of symptomatic intermediate carotid artery stenosis. Increased MPV and PDW may be independent predictors of developing symptomatic carotid artery plaque.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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