Relation Between Serum Total Bilirubin Levels and Severity of Coronary Artery Disease in Patients With Non-ST-Segment Elevation Myocardial Infarction

Author:

Kaya Mehmet Gungor1,Sahin Omer1,Akpek Mahmut1,Duran Mustafa1,Uysal Onur Kadir2,Karadavut Serhat1,Cosgun M. Said1,Savas Goktug1,Baktir Ahmet Oguz2,Sarli Bahadir2,Lam Yat Yin3

Affiliation:

1. Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey

2. Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey

3. Department of Cardiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR

Abstract

We studied 403 consecutive patients with non-ST-segment elevation myocardial infarction (NSTEMI). This population was divided into tertiles according to the SYNTAX score (SXscore). The high SXscore group was defined as an SXscore ≥13, and the low SXscore group as an SXscore <13. The total bilirubin (sTB) and direct bilirubin levels of patients were significantly higher in the high SXscore group ( P = .001 and P = .007, respectively). There was a correlation between sTB and SXscore ( r = .495; P = .005). On multivariate linear regression analyses, age (β = .100; P = .041), sTB levels (β = .171; P = .005), low-density lipoprotein cholesterol (β = .121; P = .014), and troponin-I (β = .124; P = .011) remained independent correlates of high SXscore. The mean follow-up period was 18.2 months. All-cause mortality rate was higher in the high SXscore group but did not reach significance ( P = .058). In conclusion, high sTB level is independently associated with severity of coronary artery disease in patients with NSTEMI. However, no association was found with long-term mortality.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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