Skin Flow The Venoarteriolar Response and Capillary Filtration in Diabetics. A 3-year Follow-Up

Abstract

Resting skin blood flow (RF) and the venoarteriolar response (VAR = the vasocontrictor response on standing) have been studied in 100 patients with dia betic neuropathy, in 100 diabetics without neuropathy, and in 100 normal sub jects by laser Doppler flowmetry. Capillary filtration was also studied with strain gauge plethysmography. The authors followed up these patients by evaluating their microcirculation again after three years. At the beginning of the study in patients with neuropathy, RF and capillary filtration were increased. The VAR and the microangiopathy index (MI = VAR/RF) were reduced in all diabetics, to a greater extent to those with neuropathy. After three years the authors observed an increase in capillary filtration as sociated with a further impairment in VAR and MI, suggesting progression of microangiopathy in both groups of diabetics. These results suggest that the postural control of blood flow in the skin of the foot is impaired in diabetic microangiopathy, particularly in neuropathics. Increased skin blood flow and capillary filtration and the impaired venoarterio lar response cause edema and may contribute to the thickening of capillary base ment membranes and the progressive evolution of diabetic microangiopathy.