Mean Platelet Volume and Extent and Complexity of Coronary Artery Disease in Diabetic and Nondiabetic Patients With ST Elevation Myocardial Infarction

Abstract

We investigated whether the mean platelet volume (MPV) is associated with the extent and complexity of coronary artery disease in patients with ST elevation myocardial infarction (STEMI). We prospectively included 912 STEMI patients (663 male and 249 female; mean age 58.7 ± 12.4 years) who underwent primary percutaneous coronary intervention. The patients were divided into 3 groups according to MPV tertiles. Highest SYNTAX score (SS) was observed in MPVhigh group compared with MPVmid and MPVlow groups ( P < .001 for all). The SS of MPVmid group was higher than MPVlow group ( P = .036). The MPV in diabetic STEMI patients was higher than in nondiabetic STEMI patients ( P < .001). Multivariate linear regression analysis showed that the MPV was associated with diabetes (β = .115, P = .001), troponin level (β = .131, P = .001), platelet count (β = −.241, P < .001), and SS (β = .216, P < .001). The relation between MPV and SS in diabetic STEMI patients was stronger than for nondiabetic STEMI patients ( r = .473, P < .001 vs r = .129, P = .001).