Affiliation:
1. SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche (MB, LC, AB, AS, MA, RD, LP, GF)
2. SCDU Neuroradiologia, Dipartimento di Diagnostica per Immagini (MFF), Azienda Sanitaria San Giovanni Battista, Turin, Italy.
Abstract
Objective This study investigated whether high-sensitivity C-reactive protein (hs-CRP) levels are independently associated with subclinical peripheral atherosclerosis. Methods. Clinical variables, cardiovascular (CV) risk factors, 10-year CV risk, the antebrachial Index (ABI), and the carotid intima—media thickness (cIMT) were determined in a sample of consecutive subjects free from previous CV disease, admitted for a first visit at a lipid clinic. Results. In the overall sample (320 subjects, mean age 63 years, 35.8% men), hs-CRP levels were associated with major CV risk factors, 10-year CV risk, lower ABI, and higher cIMT values. In a logistic model, after adjustment for significant covariates, the associations of hs-CRP levels with ABI and cIMT were no longer statistically significant. Conclusions. Among asymptomatic, moderate- to-high CV risk subjects, hs-CRP levels were associated with severity of peripheral atherosclerosis, but these associations were not independent of traditional CV risk factors, suggesting a limited predictive role of hs-CRP for subclinical atherosclerosis.
Subject
Cardiology and Cardiovascular Medicine
Cited by
6 articles.
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