Contrast-Induced Acute Kidney Injury Is Associated With Long-Term Adverse Events in Patients With Acute Coronary syndrome

Author:

Uzunhasan Isil1,Yildiz Ahmet1,Arslan Sukru2,Abaci Okay1,Kocas Cuneyt1,Kocas Betul Balaban3,Cetinkal Gokhan3,Dalgic Yalcin1,Karaca Osman Sukru1,Dogan Sait Mesut1

Affiliation:

1. Department of Cardiology, Cardiology Institute of Istanbul University, Istanbul University, Istanbul, Turkey

2. Department of Cardiology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey

3. Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

Abstract

Contrast-induced acute kidney injury (CI-AKI) is associated with increased mortality, morbidity, and prolonged hospitalization. Patients with acute coronary syndrome (ACS) have a 3-fold higher risk of developing CI-AKI. The aim of our study was to evaluate the predictors of CI-AKI and long-term prognosis in patients with ACS who developed CI-AKI (1083 patients were enrolled). Contrast-induced acute kidney injury was defined as an increase of ≥0.5 mg/dL and/or an increase of ≥25% of pre-percutaneous coronary intervention (PCI) to post-PCI serum creatinine levels within 48 to 72 hours after the procedure. Primary end point was defined as all-cause mortality, myocardial infarction, and cerebrovascular event at long-term follow-up (36 ± 12 months). Contrast-induced acute kidney injury occurred in 178 (16.4%) of the 1083 patients. The primary end points were significantly high in patients with ACS who developed CI-AKI ( P < .001). The occurrence of CI-AKI was identified as an independent predictor of primary end point. Risk of CI-AKI development was more frequently seen in patients with ACS. Also, patients who developed CI-AKI have worse prognosis at long-term follow-up. Additional preventive treatment strategies need to be developed in this group of patients.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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