Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats-Reference-Cited by-同舟云学术

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Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats

Published:2011-10-17 Issue:6 Volume:63 Page:416-419
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Voucharas Christos¹²,Tagarakis Georgios¹,Lazou Antigoni²,Triposkiadis Filippos¹,Tsilimingas Nikolaos¹

Affiliation:

1. Department of Cardiovascular and Thoracic Surgery, School of Medicine, University of Thessaly, Larissa, Greece

2. Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319711423529

Reference27 articles.

1. Molecular Mechanisms of Myocardial Remodeling

2. Development of isoproterenol-indueed cardiac hypertrophy

3. Animal models of human cardiovascular disease, heart failure and hypertrophy

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