Differential Effects of Nifedipine on Plasma Atrial Natriuretic Peptide in Normal Subjects and Hypertensive Patients

Author:

Shigematsu Satoshi1,Yamada Takashi1,Aizawa Toru1,Takasu Nobuyuki1,Shimizu Zenji2

Affiliation:

1. Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto-shi

2. Department of Medicine, Hokushin General Hospital, Nakano-shi, Nagano-ken, Japan

Abstract

The physiology of atrial naturiuretic peptide (ANP) secretion was studied in normotensive subjects and hypertensive patients both young and old. Basal plasma ANP concentration was least in young normotensives, intermediate in old normotensives and young hypertensives, and highest in old hypertensives. Nifedipine, a known stimulator of ANP secretion, acutely increased plasma ANP in young and old normotensive subjects but not in young hypertensive patients and half of the old hypertensive patients. Increase in serum ANP level in response to nifedipine did not augment its hypotensive effect. However, the increase of aldosterone in response to nifedipine-induced rise in plasma renin activity (PRA) seemed to be suppressed by elevated ANP.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The effects of medications on circulating levels of cardiac natriuretic peptides;Annals of Medicine;2007-01

2. Atrial natriuretic peptide contributes to the antihypertensive action of many drugs;European Journal of Drug Metabolism and Pharmacokinetics;2003-03

3. Plasma atrial natriuretic peptide levels in essential hypertension after treatment with verapamil;European Journal of Drug Metabolism and Pharmacokinetics;2002-03

4. Effects of Nifedipine Treatment on the Renin-Angiotensin-Aldosterone Axis;Journal of Clinical Endocrinology & Metabolism;1997-02-01

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