High Risk of Peripheral Arterial Disease in the United Kingdom: 2-Year Results of a Prospective Registry-Reference-Cited by-同舟云学术

High Risk of Peripheral Arterial Disease in the United Kingdom: 2-Year Results of a Prospective Registry

Published:2011-01-10 Issue:2 Volume:62 Page:111-118
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Stansby Gerard¹,Mister Rebecca²,Fowkes Gerry³,Roughton Michael⁴,Nugara Fiona⁴,Brittenden Julie⁵,Bradbury Andrew⁶,Ashley Simon⁷,Shearman Cliff⁸,Hannon Ray⁹,Flather Marcus¹⁰,

Affiliation:

1. Northern Vascular Unit, University of Newcastle, Freeman Hospital, Newcastle, UK,

2. Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK, NHMRC Clinical Trials Centre, University of Sydney, Australia

3. Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, UK

4. Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK

5. Vascular Surgery Department, Aberdeen Royal Infirmary, Aberdeen, UK

6. University Department of Vascular and Endovascular Surgery, Heart of England NHS Foundation Trust Birmingham, UK

7. Vascular Surgery Department, Derriford Hospital, Plymouth, UK

8. University Department of Vascular Surgery Southampton General Hospital, Southampton, UK

9. Vascular Surgery Department, Belfast City Hospital, Belfast, UK

10. Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK, National Heart and Lung Institute, Imperial College London, UK

Abstract

We report a prospective 2-year, multicenter study of patients presenting with intermittent claudication (IC; ankle brachial blood pressure index, ABPI ≤ 0.9). Mean age of the 473 patients enrolled was 68 years, 20% were diabetics, 30% had prior symptomatic coronary heart disease (CHD), 7% had prior stroke, and 39% were current smokers. At baseline, 26.2% of patients had BP ≤ 140/85 mm Hg or lower and at 2 years this figure was 32.5% (P = .01). Current smokers had fallen to 27% (from 39%) at 2 years (P < .001). Use of antiplatelet agents, statins, and angiotensin converting enzyme inhibitors increased significantly during the course of the study as did claudication distance. Death and the composite of death, stroke or myocardial infarction (MI), occurred in 8.4% and 11.6% of patients, respectively. Prognosis was worse in patients with prior history of CHD, older age, those with diabetes and a lower ABPI.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319710387917

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