The Effects of Continuous Renal Replacement on Anti-infective Therapy in the Critically Ill

Abstract

Acute renal failure represents a frequent, severe complication in critically ill patients leading to a direct increase in mortality and resource utilization. Today, continuous renal replacement therapy (CRRT) has replaced traditional hemodialysis, providing more precise fluid and metabolic control and decreased hemodynamic instability. There are a limited number of studies conducted for the ideal dosing of individual anti-infective agents for patients receiving CRRT. However, knowledge of the basic principles of CRRT, in conjunction with pharmacokinetics and pharmacodynamics of anti-infectives, allows sound dosing recommendations to be formulated to ensure maximal killing effects with minimal risk of toxicity in patients receiving CRRT.