Probable Labetalol-Induced Hepatotoxicity

Abstract

This article reports a case of probable hepatotoxicity induced by therapeutic doses of labetalol. A 34-year-old postpartum woman was started on labetalol during a preeclamptic episode in the hospital. During the patient's 4-week postpartum office visit, she reported having dark urine for the previous 2 weeks. A liver function test showed substantial enzyme elevation, which improved after discontinuation of labetalol therapy. Labetalol-induced hepatotoxicity, although uncommon, can occur. Published data report this occurrence only in middle-aged or older patients. This appears to be the first case report of postpartum labetalol-induced hepatotoxicity. Hepatotoxicity may occur as a result of labetalol therapy. More judicious monitoring in patients on labetalol therapy may be warranted to prevent serious outcomes.