An Overview of Heparin-Induced Thrombocytopenia-Reference-Cited by-同舟云学术

An Overview of Heparin-Induced Thrombocytopenia

Published:2010-04-13 Issue:3 Volume:23 Page:226-234
ISSN:0897-1900
Container-title:Journal of Pharmacy Practice
language:en
Short-container-title:Journal of Pharmacy Practice

Author:

Donovan Jennifer L.¹²,Tran Maichi T.²,Kanaan Abir O.¹³

Affiliation:

1. Massachusetts College of Pharmacy and Health Sciences, Worcester, MA, USA

2. Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA, USA

3. Department of Pharmacy, St. Vincent Hospital, Worcester, MA, USA

Abstract

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction to heparin products leading to a prothrombotic state. Devastating clinical sequelae may result, including venous or arterial thromboembolism, limb amputation, and death. Heparin cessation alone is insufficient to manage HIT. Pharmacotherapy with argatroban or lepirudin is essential. This article reviews the pathogenesis, diagnosis, and pharmacotherapy of HIT.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1177/0897190010362171

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