A Case Report of Sudden Sensorineural Hearing Loss (SSNHL) After Administration of the COVID-19 Vaccine

Author:

Andrade Justin12ORCID,Sessa Lauren3,Ephrat Moshe3,Truong James2,DiGregorio Robert2

Affiliation:

1. Department of Pharmacy Practice, Touro College of Pharmacy, New York, NY, USA

2. Pharmacotherapy Department, The Brooklyn Hospital Center, Brooklyn, NY, USA

3. ENT & Allergy Associates LLP, Lake Success, NY, USA

Abstract

Since the issuance of the emergency use authorization (EUA) of 3 coronavirus disease 2019 (COVID-19) vaccines, there have been over 180 million individuals fully vaccinated in the United States (US). With the increasing administration of COVID-19 vaccinations, there have been over 550,000 adverse events reported in the Vaccine Adverse Event Reporting System (VAERS) with approximately 230,000 experienced after receipt of the Pfizer-BioNTech COVID-19 Vaccine as of September 23rd 2021. Audio-vestibular symptoms (including Sudden Sensorineural Hearing Loss (SSNHL)) secondary to immunizations has previously been evaluated. However, this report describes the first case of bilateral sudden sensorineural hearing loss potentially due to the Pfizer-BioNTech COVID-19 vaccine. We further review the available literature regarding the treatment of Sudden Sensorineural Hearing Loss, and the association of SSNHL with previous immunizations and COVID-19 infection. Lastly, we hypothesize the underlying potential mechanisms between SSNHL and the Pfizer-BioNTech COVID-19 vaccine.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Reference28 articles.

1. Ferré-Sadurní L, Goldstein J. 1st vaccination in U.S. is given in New York, hard hit in outbreak’s first days. New York Times. 2020. Published https://www.nytimes.com/2020/12/14/nyregion/coronavirus-vaccine-new-york.html Accessed December, 30, 14, 2020.

2. US Food and Drug Administration (FDA). Fact sheet for healthcare providers administering vaccine: Emergency Use Authorization (EUA) of the Moderna COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19): primary series and booster dose presentation. Updated August 31, 2022a. https://www.fda.gov/media/157233/download https://www.fda.gov/media/157233/download Accessed September 14, 2022.

3. US Food and Drug Administration (FDA). Fact sheet for healthcare providers administering vaccine: Emergency Use Authorization (EUA) of the Janssen COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Updated. https://www.fda.gov/media/146304/download https://www.fda.gov/media/146304/download Accessed September 5, 14, 2022.

4. Preliminary Analysis of Association Between COVID-19 Vaccination and Sudden Hearing Loss Using US Centers for Disease Control and Prevention Vaccine Adverse Events Reporting System Data

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