Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis

Author:

Wang Meihua1,Sun Yaping2ORCID

Affiliation:

1. Department of Respiration, XiXi Hospital of Hangzhou, Hangzhou, China

2. Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China

Abstract

Background A meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer. Methods We systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results Seven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. TERT rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58–2.12; AG vs. GG: OR=1.21, 95% CI=1.10–1.34; Dominant model: OR=1.33, 95% CI=1.22–1.46; Recessive model: OR=1.66, 95% CI=1.44–1.90). Moreover, this polymorphism was found to be correlated with the susceptibility to lung cancer when studies were stratified based on the sample size and the Hardy–Weinberg equilibrium. Conclusion The present findings indicate that the TERT rs2736098 polymorphism may be a risk factor for the development of lung cancer.

Funder

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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