Vascular Effects of Cinnarizine in Patients with Intermittent Claudication

Abstract

An ECG-triggered venous occlusion Plethysmographic method to provide an index of arterial inflow, has been used in 10 patients with angiographic confirmed intermittent claudication. The differential quotient of the Plethysmographic arterial pulse has been used to provide an index of pulse wave velocity. The effect of cinnarizine, a drug which acts probably by inhibiting the calcium influx into vascular smooth muscle cells, was measured after three and seven days of administration. In this trial cinnarizine increased blood flow to the lower limb following exercise.