Affiliation:
1. Department of Ultrasound, First Affiliated Hospital of Hebei North University, Zhangjiakou, China
2. Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, China
3. Department of General Surgery, First Affiliated Hospital of Hebei North University, Zhangjiakou, China
4. Department of Endocrinology, First Affiliated Hospital of Hebei North University, Zhangjiakou, China
Abstract
Objective To investigate the relationships among serum resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Methods A total of 120 patients with T2DM were divided into non-microangiopathy and microangiopathy groups. Sixty age- and sex-matched healthy subjects were used as a normal control (NC) group. Body height, body mass, waist circumference, and blood pressure were determined, and waist/hip ratio (WHR), body mass index, blood glucose, lipids, resistin, leptin, adiponectin, free fatty acids (FFA), high-sensitivity C-reactive protein (hs-CRP), fasting insulin, hemoglobin A1c, and homeostatic model assessment of insulin resistance (HOMA-IR) were compared among the three groups. Results Serum levels of resistin, leptin, FFA, and hs-CRP were significantly higher and levels of adiponectin were significantly lower in patients in the non-microangiopathy (n = 60) and microangiopathy groups (n = 60) compared with the NC group (n = 60). Serum resistin and leptin levels in patients with T2DM were positively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but negatively correlated with high-density lipoprotein-cholesterol (HDL-C). Serum adiponectin levels in patients with T2DM were negatively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but positively correlated with HDL-C. Conclusion Serum resistin, adiponectin, and leptin levels correlate with the occurrence of T2DM and microvascular complications.
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
14 articles.
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