A Double-Blind Comparative Trial of Loxapine and Trifluoperazine in Acute and Chronic Schizophrenic Patients-Reference-Cited by-同舟云学术

A Double-Blind Comparative Trial of Loxapine and Trifluoperazine in Acute and Chronic Schizophrenic Patients

Published:1976-11 Issue:6 Volume:4 Page:441-448
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Kiloh L G¹,Williams S E²,Grant D A³,Whetton P S⁴

Affiliation:

1. Professor of Psychiatry, University of New South Wales, Australia

2. Staff Psychiatrist, Callan Park Hospital, Rozelle, New South Wales, Australia

3. Staff Psychiatrist, Neuropsychiatric Institute, Rozelle, New South Wales, Australia

4. Staff Pschiatrist, Callan Park Hospital, Rozelle, New South Wales, Australia

Abstract

A double-blind comparative trial of loxapine and trifluoperazine was carried out in 57 acute and chronic schizophrenic patients. In both groups of patients loxapine proved to be equivalent in its effects to trifluoperazine and there were suggestions it might be rather more effective in chronic patients. Side-effects were simitar with the two drugs but anticholinergic effects, excitement, dizziness and faintness occurred rather more commonly with loxapine. Laboratory tests, urine analysis, cardiovascular and ophthalmological investigations showed no significant abnormalities.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006057600400611

Reference16 articles.

1. Loxapine in Newly Admitted Chronic Schizophrenic Patients

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