Three-Day Clotrimazole Therapy for Vulvo-Vaginal Mycosis

Abstract

A self-medication therapy with clotrimazole vaginal tablets, application of two tablets at bedtime on 3 consecutive days, was carried out to find out whether vulvo-vaginal mycoses can be treated more effectively and with fewer drop-outs when treatment is simpler and shorter. Our study included forty-one patients, seventeen of whom were in their second or third trimester of pregnancy. There was no significant difference between the efficacy rates in the pregnant (82·4%) and non-pregnant (83·3%) women. In 36 infections caused by various Candida species the cure rate was 91·7%; in 8 infections due to Torulopsis glabrata it was 75%. For thirty-three women with primary infections the cure rate was 84·8% and for eight women with recurrent infections it was 75%. The cure rate for the entire group of patients was 82·9% (thirty-four out of forty-one cases). Failures were seen in six out of thirty cases, i.e. in 16·7%. In one case burning was experienced after the insertion of the vaginal tablet so that treatment was discontinued.