Relationship between cerebral microbleeds and cognitive function in lacunar infarct

Abstract

Objective Little is known about the impact of cerebral microbleeds on cognitive function. This study investigated the distribution of cerebral microbleeds and their impact on cognitive function, in patients with lacunar infarct. Methods Patients with lacunar infarct were enrolled prospectively. Cerebral microbleeds were classified as absent, mild, moderate or severe, based on magnetic resonance imaging findings. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) questionnaire, with a total score of <26 indicating cognitive impairment. Results Of the 85 patients included in the study, 35 (41.2%) had cerebral microbleeds. They were more frequently observed in mixed and deep brain regions, but rarely in the cerebral lobes. Multiple logistic regression analysis demonstrated that presence of cerebral microbleeds (odds ratio [OR] 5.320), duration of education (OR 0.938) and age (OR 1.464) were independent predictors of cognitive impairment. There was a significant correlation between cerebral microbleed severity and MoCA score. Conclusion The number and location of cerebral microbleeds were both closely associated with cognitive impairment, in patients with lacunar infarct.