Prognostic value of serum paraoxonase and arylesterase activity in patients with sepsis

Abstract

Objective To determine whether serum paraoxonase (PON) and arylesterase (ARE) activity might predict sepsis mortality. Methods Patients with sepsis and healthy control subjects were enrolled in this retrospective study. Serum PON and ARE activity levels were measured. Patients were stratified according to 30-day mortality rates. Results Serum PON and ARE activity levels were significantly lower in patients with sepsis ( n = 61) than in healthy controls ( n = 32), and were significantly lower in nonsurviving patients ( n = 22) than in surviving patients ( n = 39). Low PON and ARE activity levels were significantly correlated with poor overall survival in patients with sepsis. Conclusions Decreased serum PON and ARE activity is related to poor prognosis in patients with sepsis. Measuring the activity of PON and ARE may represent a new method for evaluating the prognosis of sepsis. In addition, both PON and ARE are potential molecular treatment targets for sepsis.