Affiliation:
1. Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, China
Abstract
Objective To investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension. Methods Patients with T2DM (n = 384) and healthy volunteers (n = 80) were enrolled into this study. Serum NPY, α-MSH, and AgRP levels were detected using ELISA. Results Significantly higher NPY and lower α-MSH and AgRP levels were observed in patients with diabetes compared with those without diabetes, and the mean NPY levels increased, while α-MSH and AgRP levels decreased, with the development of hypertension compared with diabetic patients without hypertension. α-MSH and AgRP levels decreased with an increase in blood pressure in hypertension compared with the non-hypertension patients. Multiple stepwise linear regression analysis showed that NPY, α-MSH, and AgRP levels were closely associated with blood pressure and glucose control. Receiver operating characteristic (ROC) curve analyses indicated that α-MSH may be a better marker compared with NPY and AgRP for regulating glucose and blood pressure and to distinguish between T2DM patients with and without hypertension. Conclusion NPY, α-MSH, and AgRP might play different roles and be closely related to the occurrence and development of diabetes and hypertension.
Funder
Baoding Science and Technology Research and Development Project
Project of National Natural Science Foundation of China
Project of Hebei Medical Science Research
Subject
Biochemistry (medical),Cell Biology,Biochemistry,General Medicine
Cited by
5 articles.
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