Affiliation:
1. Pulmonary Department, Evangelismos Hospital, Athens, Greece; Pulmonary Department, Athens University, Athens, Greece
Abstract
Patients with Gram-negative lower respiratory tract infections (acute exacerbation of chronic bronchitis ( n = 23), pneumonia ( n = 4), and bronchiectasis ( n = 5) were treated with pefloxacin, 400 mg twice daily, given either intravenously or orally. Symptoms, signs and sputum volume and colour were monitored daily. Chest X-rays, sputum culture and Gram-stain examinations were carried out on days 1 and 5, and immediately after the end of the treatment. There was a clinical improvement, as indicated by the incidence of cough, dyspnoea and rales, and by sputum volume and colour in 31 patients (97%). Microbiological improvement, as indicated by the complete elimination of sputum pathogens and pus cells, was achieved in 28 of the patients (88%). In one patient, an adverse effect, renal failure, occurred. These results suggest that pefloxacin is both clinically and microbiologically effective for the treatment of Gram-negative lower respiratory tract infections.
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
1 articles.
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