Roles and signaling pathways of CITED1 in tumors: overview and novel insights

Author:

Chen Wenting12,Jiang Jianing12ORCID,Gao Jinqi3,Wang Gang1,Wang Ruoyu12,Lv Jinyan1,Ben Jing1

Affiliation:

1. Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China

2. The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China

3. Department of Intervention, The Second Hospital Affiliated to Dalian Medical University, Dalian, China

Abstract

CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is a transcriptional activator belonging to the non-DNA-binding transcription co-regulator family. It regulates diverse pathways, including the transforming growth factor/bone morphogenetic protein/SMAD, estrogen, Wnt-β-catenin, and androgen-AR signaling pathways, by binding to CBP/p300 co-activators through its conserved transactivation domain CR2. CITED1 plays an important role in embryonic development and a certain regulatory role in the occurrence and development of various tumors. In this article, the biological characteristics, expression regulation, participating signaling pathways, and potential roles of CITED1 in the clinical diagnosis and treatment of tumors are reviewed.

Funder

the Research Project of Dalian Medical Science

the Doctor Study-up Foundation of Liaoning Province

the High level talent innovation support plan of Dalian

the National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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