Outcomes of combination treatment with MARS and TIPS for hepatic veno-occlusive disease: a report of 12 cases

Author:

Deng Li1,Yin Xiuli2,Zhao Yingying1,Yang Jing1,Yang Hongli1,Xu Changqing1,Li Kun1ORCID

Affiliation:

1. Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China

2. Department of Gastroenterology, Rongjun Hospital of Shandong Province, Jinan, China

Abstract

Background In patients with acute liver injury caused by hepatic veno-occlusive disease (HVOD), molecular adsorbent recirculation system (MARS) may be used to improve liver function in conjunction with transjugular intrahepatic portosystemic shunt (TIPS) to reduce portal hypertension. Methods Twelve patients were admitted to our hospital following treatment for HVOD for 10 to 21 days at other hospitals. All patients were treated with a combination of MARS and TIPS, and they were evaluated clinically including liver function tests. Results After the initial treatment with MARS, liver function improved significantly in all patients. TIPS placement decreased the hepatic venous pressure gradient (HVPG) to 10.17 ± 2.26 mmHg from a pre-TIPS HVPG of 23.58 ± 9.43 mmHg. The outcomes of combination treatment with MARS and TIPS in 12 patients with HVOD were as follows: 1) improvement of various clinical and biological parameters leading to full recovery in 1 year in 6 patients; 2) full recovery following liver transplantation for acute liver failure in three patients; and 3) three patients died due to hepatic failure after TIPS placement. Conclusion The combination of MARS and TIPS creation is promising as a potential treatment for acute HVOD, and it showed an improvement in overall survival.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

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