Lung cancer with breast metastasis: a case report and review of the literature

Author:

Cao Xuan1ORCID,Chen Peiqing1,Agyekum Enock Adjei2,Zhang Qing2ORCID,Qian Xiaoqin2,Wu Ting3,Chambers Kevoyne Hakeem4ORCID,Yin Liang1ORCID

Affiliation:

1. Department of Breast Surgery, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

2. Department of Ultrasound, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

3. Department of Pathology, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

4. School of Medicine, Jiangsu University, Zhenjiang, China

Abstract

In this article, we present a rare case of breast metastasis of lung cancer. Chest computed tomography (CT) for a woman in her early 50s indicated right lung malignancy, multiple bone metastases, and an irregular mass in her right breast. Further inquiry into the case history revealed that the patient had been aware of the breast mass for 3 years, without respiratory symptoms. Biopsy of the breast mass suggested estrogen receptor (ER) (+), progesterone receptor (PR) (−), and human epidermal growth factor receptor 2 (HER2) (+ +) breast cancer. The patient was initially diagnosed with breast cancer with lung and bone metastasis. However, comprehensive breast cancer treatment was ineffective, and thyroid transcription factor-1 (TTF-1), napsin A, and cytokeratin 7 (CK7) were evaluated to better understand the origin of the cancer. To the best of our knowledge, this patient had the longest reported disease course from presentation with a breast lump as the first symptom to the final diagnosis of breast metastasis of lung cancer. To provide a better reference for differential diagnosis of ambiguous tumors, we also performed a systematic literature review.

Funder

Jiangsu University Medical Education and Research Collaborative Innovation Fund

Research Project of Jiangsu Maternal and Child Health Association

National Natural Science Foundation of China

Clinical Research Project of the Jiangsu University Affiliated People's Hospital

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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