Genetic polymorphisms of pri-let-7f, gene–environment and gene–gene interactions, and associations with ischemic stroke risk in Liaoning Province

Author:

Qiu Luying1ORCID,Wang Yuye12,Liu Fang1,Deng Shumin1,He Zhiyi1ORCID,Zheng Wenxu3,Wang Yanzhe1

Affiliation:

1. Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China

2. Department of Neurology, China-Japan Friendship Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

3. Geriatric Department of Dalian Friendship Hospital, No. 8 Sanba Square, Dalian, China

Abstract

Objective The incidence of stroke has been rising annually and investigations into traditional risk factors have led to increased attention on genetic factors. In this study, we focused on the pri-let-7f gene, and investigated the association between pri-let-7f gene polymorphisms and ischemic stroke (IS). Methods This case–control study included 1803 patients and 1456 healthy controls of Han ethnicity living in Liaoning Province. We carried out genotyping analysis of two loci, pri-let-7f-1 rs10739971 and pri-let-7f-2 rs17276588, and performed statistical analysis controlling for confounding factors by logistic regression. Results The A alleles and AA genotypes of both loci were significantly associated with an increased risk of IS. Variant genotypes of rs17276588 may also increase the risk of IS in females with alcohol intake. Gene–gene interaction analysis showed combined effects of mutations in both these single nucleotide polymorphisms (SNPs). Conclusions This study demonstrated an association between pri-let-7f SNPs and IS, providing potential latent biomarkers for the risk of IS. However, more detailed studies are needed to clarify these results.

Funder

Natural Science Foundation of Liaoning Province of China

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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