Affiliation:
1. Department of Dermatology, Kansai Medical University, Osaka, Japan
Abstract
The effect of roxithromycin (ROM), a new oral semisynthetic macrolide, on the generation of reactive oxygen species (ROS), using human neutrophils and a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were the superoxide radical anion (O2−), hydrogen peroxide (H2O2), and the hydroxyl radical (OH·). ROM effectively inhibited the generation of O2−, H2O2 and OH· by human neutrophils. On the other hand, the drug did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ROM may exert an anti-inflammatory action by inhibiting neutrophil oxygen radical generation at the sites of inflammation.
Subject
Biochemistry (medical),Cell Biology,Biochemistry,General Medicine
Cited by
13 articles.
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