The Effect of Roxithromycin on the Generation of Reactive Oxygen Species In Vitro

Author:

Akamatsu H1,Nishijima S1,Akamatsu M1,Kurokawa I1,Sasaki H1,Asada Y1

Affiliation:

1. Department of Dermatology, Kansai Medical University, Osaka, Japan

Abstract

The effect of roxithromycin (ROM), a new oral semisynthetic macrolide, on the generation of reactive oxygen species (ROS), using human neutrophils and a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were the superoxide radical anion (O2), hydrogen peroxide (H2O2), and the hydroxyl radical (OH·). ROM effectively inhibited the generation of O2, H2O2 and OH· by human neutrophils. On the other hand, the drug did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ROM may exert an anti-inflammatory action by inhibiting neutrophil oxygen radical generation at the sites of inflammation.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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