Dextromethorphan and Codeine: Objective Assessment of Antitussive Activity in Patients with Chronic Cough

Author:

Matthys Heinrich1,Bleicher Bärbel2,Bleicher Ulrich2

Affiliation:

1. Professor of Medicine, Director of Clinic, Department of Pulmonary Disease, University Medical Clinic, D-7800 Freiburg i Br, West Germany

2. Physician, Department of Pulmonary Disease, University Medical Clinic, D-7800 Freiburg i Br, West Germany

Abstract

Dextromethorphan, the most widely used cough suppressant in the U.S.A., was compared with codeine, the traditional European antitussive, in a double-blind, crossover trial using both an objective and subjective assessment of efficacy in sixteen patients with chronic, stable cough. Both preparations, at a dose of 20 mg, were similarly effective in reducing cough frequency. Dextromethorphan lowered cough intensity to a greater degree than codeine (p < 0·0008) and was considered the better antitussive by the majority of patients (p < 0·001). In view of its lack of side-effects, its safety even in overdose and its non-narcotic status, the increasing trend in Europe to use dextromethorphan as a substitute for codeine in the treatment of cough is to be welcomed.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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