A Multicentre Comparison of Flurbiprofen and Naproxen in Rheumatoid Arthritis: A Four-Week Study in 118 Patients-Reference-Cited by-同舟云学术

A Multicentre Comparison of Flurbiprofen and Naproxen in Rheumatoid Arthritis: A Four-Week Study in 118 Patients

Published:1983-03 Issue:2 Volume:11 Page:85-89
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Ligniere G Cherie¹,Còlamussi V²,Cozzolongo A C³,Loizzi P³,Frizziero L⁴,Mattara L⁵,Zorzin L⁶

Affiliation:

1. Cattedra di Reumatologia, – Universitá di Milano, Italy

2. Divisione di Mediana, – Ospedale S. Giuseppe, – Copparo (FE), Italy

3. Cattedra di Reumatologia, – Università di Bari, Italy

4. Centro Traumatologico Ortopedico, – Bologna, Italy

5. Divisione di Reumatologia, – Ospedale Al Mare, – Venezia Lido, Italy

6. Istituto di Reumatologia, – Università di Roma, Italy

Abstract

One-hundred and eighteen patients with rheumatoid arthritis were treated for 4 weeks with flurbiprofen 300 mg/day (sixty patients) or naproxen 750 mg/day (fifty-eight patients) in a six-centre randomized trial. Flurbiprofen proved to be more effective than naproxen in reducing morning stiffness (p < 0·01), Ritchie articular index (p < 0·01) and number of swollen joints (p < 0·05) and in relieving night pain (p < 0·01). The incidence and severity of side-effects, mainly gastric, were both low and similar with flurbiprofen (17%) and naproxen (19%).

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006058301100204

Reference11 articles.

1. Inhibition of prostaglandin synthesis and leucocyte migration by flurbiprofen

2. Prostaglandin synthetase inhibitors and leucocytic emigration

3. Naproxen

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