Optimal dilution of contrast medium for quantitating parenchymal blood volume using a flat-panel detector

Author:

Kuriyama Takumi1,Sakai Nobuyuki23,Beppu Mikiya3,Sakai Chiaki2,Imamura Hirotoshi3,Kojima Iwao4,Masago Katsuhiro5,Katakami Nobuyuki5

Affiliation:

1. Division of Radiological Technology, Institute of Biomedical Research and Innovation, Kobe, Japan

2. Division of Neuro-endovascular Therapy, Institute of Biomedical Research and Innovation, Kobe, Japan

3. Division of Neurosurgery, Kobe City Medical Center General Hospital, Kobe, Japan

4. AT Innovation Department, Advanced Therapies Business Area, Siemens Healthcare K.K., Tokyo, Japan

5. Division of Integrated Oncology, Institute of Biomedical Research and Innovation, Kobe, Japan

Abstract

Objective Similar to perfusion studies after acute ischemic stroke, measuring cerebral blood volume (CBV) via C-arm computed tomography before and after therapeutic interventions may help gauge subsequent revascularization. We tested serial dilutions of intra-arterial injectable contrast medium (CM) to determine the optimal CM concentration for quantifying parenchymal blood volume by flat-panel detector imaging (FD-PBV). Methods CM was diluted via saline power injector, instituting time delays for FD-PBV studies. A red/green/blue (RGB) color scale was employed to quantify/compare FD-PBV and magnetic resonance-derived CBV (MRCBV). Results Contrast values of right and left common carotid arteries did not differ significantly at CM dilutions of ≥20%. RGB analysis of FD-PBV imaging (relative to MR-CVB), showed CM dilution altered the colors (by 16%), increasing red and decreasing blue ratios. Conclusion Diluting CM to 20% resulted in no laterality differential of FD-PBV imaging, with left/right quantitative ratios approaching 1.1 (optimal for clinical use).

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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