Association between serum copper levels and lung cancer risk: A meta-analysis

Author:

Zhang Xiaping1,Yang Qun23

Affiliation:

1. Department of Vascular Surgery, the Second Xiangya Hospital of Central South University, Hunan Province, China

2. Department of Oncology, the Second Xiangya Hospital of Central South University, Hunan Province, China

3. Clinical Nursing Teaching and Research Section, the Second Xiangya Hosptial of Central South University, Hunan Province, China

Abstract

Objective To evaluate the association between serum copper levels and lung cancer risk. Methods We searched the electronic PubMed, WanFang, CNKI, and SinoMed databases to identify studies including information on serum copper levels and lung cancer. Standard mean differences and corresponding 95% confidence intervals were calculated using Stata 12.0 software. We performed a meta-analysis on the identified studies overall and according to geographic location. We also evaluated heterogeneity among the studies and the occurrence of publication bias. Results Thirty-three articles including 3026 cases and 9439 controls were included in our study. The combined results showed that serum copper levels were higher in patients with lung cancer compared with controls without lung cancer, though the results showed high heterogeneity. In a subgroup analysis according to geographic location, significant associations between copper levels and lung cancer were found for both Asian and European populations. No publication bias was detected in this meta-analysis. Conclusions High serum copper levels could increase the risk of lung cancer, suggesting that environmental copper exposure may be a risk factor for the development of lung cancer.

Funder

Psychological therapy and related research on chronic pain in cancer patients

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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