Affiliation:
1. Department of Urology, Capital Institute of Paediatrics, Beijing, China
Abstract
Objective To identify dysregulated miRNAs in testicular tissues from animal models and patients with cryptorchidism. Methods Databases were systematically searched for studies published before 10 May 2020 that had investigated miRNAs in cryptorchidism. Predicted targets of the identified miRNA biomarkers were obtained by searching TargetScan and Starbase. Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses were subsequently conducted. Results Five publications met the eligibility criteria for the review. 21 differentially expressed miRNAs were the most abundantly reported in 185 animal and human tissue samples. Three miRNAs (miR-210, miR-449a and miR-34c) were dysregulated in both animal and human testicular tissues. The top five relevant lncRNAs associated with the miRNAs were NEAT1, KCNQ1OT1, XIST, AC005154.1, and TUG1. Conclusions Further research is warranted to explore the potential of these dysregulated miRNAs as biomarkers or therapeutic targets for male infertility associated with cryptorchidism.
Funder
The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority
The Key Medical Specialty Development Plan of Beijing Hospital Administration
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
4 articles.
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