Mercury as a cause of membranous nephropathy and Guillain–Barre syndrome: case report and literature review

Author:

Yawei Chen1ORCID,Jing Sun2,Wenju Shi1,Yupeng Li3ORCID,Ping Zhang1,Liping Han3

Affiliation:

1. PLA 983rd Hospital, Tianjin, China

2. The People’s Hospital of QianNan, Duyun, China

3. Chu Hsien-I Memorial Hospital, Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China

Abstract

Secondary renal involvement in chronic exposure to metallic mercury is well known. Mercury also causes central nervous system damage and demyelinating polyneuropathy. Here, we describe a case of a patient with daily exposure to mercury in skin lightening cream and hair dyes who was diagnosed with Guillain–Barre syndrome and then developed nephrotic syndrome because of membranous neuropathy. By reviewing the literature describing mercury-associated diseases, we found that mercury components have an immunomodulatory activity, which is also involved in both peripheral neuropathy and glomerulonephritis.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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