Nomogram prediction of caries risk among schoolchildren age 7 years based on a cohort study in Shanghai

Author:

Luo Yuan12ORCID,Zhang Hao13,Zeng Xiaoli3,Xu Wei3,Wang Xun3,Zhang Ying3,Wang Yan13

Affiliation:

1. Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China

2. Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai, China

3. Department of Preventive Dentistry, Shanghai Stomatological Hospital, Fudan University, Shanghai, China *Hao Zhang is the Co-first author of the manuscript.

Abstract

Objective Caries risk assessment tools are essential for identifying and providing treatment for individuals at high risk of developing caries. We aimed to develop a nomogram for the assessment and evaluation of caries risk among Chinese children. Methods We enrolled schoolchildren age 7 years from a primary school in Shanghai. Baseline information of participants was collected using a questionnaire completed by children’s caregivers. A nomogram of a novel prediction scoring model was established based on predictors detected in univariate and multivariate analyses. Predictive accuracy and discriminative ability of the nomogram were calculated using the concordance index (C index). The bootstrap method (1000 samples) was used to decrease overfitting. The net benefit of the model was validated using decision curve analysis. Results Overall, 406 children with complete information and two completed dental examinations were included in the final analysis. The nomogram based on logistic regression model coefficients demonstrated a C index of 0.766 (95% confidence interval: 0.761–0.771) for caries risk. The net benefit of the decision curve analysis was 38.6% at 55% threshold probability. Conclusion This nomogram model, derived using dietary habits, oral hygiene status, and caries experience, showed promising predictive ability to assess the caries risk among Chinese children.

Funder

Clinical Research Cultivating Project of SHDC

Research Project of Shanghai Municipal Commission of Health and Family Planning

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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