Therapeutic Effects of Tiopronin on Chronic Hepatitis: A Double-Blind Clinical Study-Reference-Cited by-同舟云学术

Therapeutic Effects of Tiopronin on Chronic Hepatitis: A Double-Blind Clinical Study

Published:1982-09 Issue:5 Volume:10 Page:325-332
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Ichida F¹,Shibasaki K²,Takino T³,Suzuki H⁴,Fujisawa K⁵,Inoue K⁶,Hirayama C⁷,Kaito I⁸,Hirasawa T⁹,Kameda H⁵,Inoue J¹⁰,Satoh G¹¹,Kosaka Y¹²,Yamamoto S¹³,Nagashima H¹⁴,Tsuji T¹⁵,Ohta Y¹⁶,Okada J¹⁷

Affiliation:

1. Department of Internal Medicine, School of Medicine, Niigata University

2. Department of Internal Medicine, Nippon Dental University, Niigata

3. Department of Internal Medicine, Kyoto Prefectural University of Medicine

4. Department of Internal Medicine, Yamanashi Medical University, School of Medicine

5. Department of Internal Medicine, The Jikei University, School of Medicine

6. Department of Internal Medicine, Toyama Medical and Pharmaceutical University Medical School

7. Department of Internal Medicine, Tottori University, School of Medicine

8. Department of Internal Medicine, Iwate Medical University, School of Medicine

9. Department of Internal Medicine, Iwaki Kyoritsu General Hospital

10. Department of Internal Medicine, Oji National Hospital

11. Mutual Aid Association Mishuku Hospital

12. Department of Internal Medicine, Mie University, School of Medicine

13. Department of Internal Medicine, Osaka City University Medical School

14. Department of Internal Medicine, Okayama University Medical School

15. Health Research Center, Okayama University

16. Department of Internal Medicine, Ehime University, School of Medicine

17. Department of Pharmaceutical Engineering, Faculty of Pharmaceutical Sciences, Kyoto University

Abstract

The efficacy of tiopronin (2-mercaptopropionyl glycine) 600 mg daily in the treatment of chronic active or chronic persistent hepatitis has been assessed in a double-blind controlled clinical trial of 12 weeks involving 165 Japanese patients with histologically proven disease. Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase and gamma glutamyl transpeptidase, with reversion towards baseline values on stopping the drug. Improvement was independent of the histological classification of the disease, or HBsAg status. The drug was well tolerated with few side-effects. The results of this short-term study indicate that tiopronin may be of value in the treatment of chronic hepatitis.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006058201000503

Reference16 articles.

1. A CLASSIFICATION OF CHRONIC HEPATITIS

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