Once-Daily Penbutolol or Atenolol Can Replace Combination Therapy in Essential Hypertension

Author:

Houtzagers J J R1,Chadha Dev R2

Affiliation:

1. Department of Internal Medicine, Diaconessenhuis, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven, The Netherlands

2. Medical Director, Hoechst Pharma, P.O. Box 284, 1000 AG Amsterdam, The Netherlands

Abstract

Antihypertensive therapy was stopped in twenty-one patients with moderate hypertension. Almost all of them had been on combination therapy, usually propranolol or metoprolol with chlorthalidone, for more than a year. After a placebo ‘wash-out’ period of 4 weeks patients were randomly allocated in a controlled trial to a fixed daily dose of either 100 mg atenolol or 40 mg penbutolol for 6 weeks. Single-agent therapy at these doses successfully controlled the blood pressure in nineteen of the twenty-one patients, including six previously inadequately controlled on a combination. Although no conclusions can be drawn about the long-term benefits, in the patient population under study either penbutolol or atenolol given at a standard dose should provide good initial blood pressure control in most patients with mild to moderate hypertension.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Newer antihypertensive agents;Postgraduate Medicine;1991-04

2. Usefulness of penbutolol for systemic hypertension;The American Journal of Cardiology;1989-06

3. Anti-anginal and beta-adrenoceptor blocking drugs;Side Effects of Drugs Annual;1983

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