Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma

Author:

Nie Jiani1ORCID,Li Lianhe2,Tan Fuxian2,Wang Hongmei2,Wang Hongmin2,Zou Liangyu2,Wen Zhenlei2

Affiliation:

1. Chengde Medical University, Heibei, China

2. Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of Chaoyang, Liaoning, China

Abstract

ObjectivesTo explore the relationship between CADM1 expression and sensitivity to TPF-induced chemotherapy in laryngeal squamous cell carcinoma (LSCC) patients, then investigate its potential mechanisms.MethodsDifferential CADM1 expression was examined in chemotherapy-sensitive and chemotherapy-insensitive LSCC patient samples after TPF-induced chemotherapy using microarray analysis. Receiver operating characteristic (ROC) curve analysis and bioinformatics approaches were used to investigate the diagnostic value of CADM1. Small interfering RNAs (siRNAs) were used to knock down CADM1 expression in an LSCC cell line. Differential CADM1 expression was compared by qRT-PCR assays in 35 LSCC patients treated with chemotherapy, including 20 chemotherapy-sensitive and 15 chemotherapy-insensitive patients.ResultsPublic database and primary patient data both suggest that CADM1 mRNA is expressed at lower levels in chemotherapy-insensitive LSCC samples, suggesting its potential usefulness as a biomarker. Knockdown of CADM1 with siRNAs led to decreased sensitivity of LSCC cells to TPF chemotherapy.ConclusionsUpregulation of CADM1 expression can alter the sensitivity of LSCC tumors to TPF induction chemotherapy. CADM1 is a possible molecular marker and therapeutic target for induction chemotherapy in LSCC patients.

Funder

Liaoning Natural Science Foundation Program

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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