Oxypertine in Combination with Imipramine: A Controlled Trial-Reference-Cited by-同舟云学术

Oxypertine in Combination with Imipramine: A Controlled Trial

Published:1978-01 Issue:1 Volume:6 Page:4-10
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Sim Myre¹,Gordon E B²,Nicol C G³

Affiliation:

1. Professor of Psychiatry, University of Ottawa, Ottawa, Canada

2. Consultant Psychiatrist, Saxondale Hospital, Nottingham, England

3. Medical Department, Winthrop Laboratories, Surbiton, England

Abstract

A method for the controlled assessment of two agents for possible interaction in the treatment of endogenous depression is described. This consisted of dose-ranging the supplementary agent (oxypertine 30 mg and 60 mg daily or matching placebo) during Week 2 to Week 6 having established all patients on a therapeutic dose of imipramine during Week 1. The reported enhancement of imipramine by oxypertine was not confirmed.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006057800600102

Reference6 articles.

1. The Influence of Benzquinamide, Oxypertine and Prenylamine on Monoamine Levels and on Monoamine Effects in the Spinal Cord

2. Differential monoamine depletion by oxypertine in nerve terminals

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