A Comparative Study of Floctafenine (Idarac) and Ibuprofen in the Treatment of Osteoarthrosis-Reference-Cited by-同舟云学术

A Comparative Study of Floctafenine (Idarac) and Ibuprofen in the Treatment of Osteoarthrosis

Published:1978-01 Issue:1 Volume:6 Page:11-13
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Rhind V M¹,Leatham P A¹,Wright V²,Akbar F A³,Downie W W⁴

Affiliation:

1. Research Metrologist, The Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, and the Rheumatism Research Unit, University Department of Medicine, General Infirmary at Leeds, England

2. Professor of Rheumatology, University of Leeds, England

3. Medical Division, Roussel Laboratories, Wembley Park, Middlesex, England

4. Clinical Pharmacologist, The Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, and the Rheumatism Research Unit, University Department of Medicine, General Infirmary at Leeds, England

Abstract

A two-by-two-week crossover trial was conducted in patients with osteoarthrosis, using a double-dummy technique of drug administration. The drugs used were floctafenine (Idarac) and ibuprofen both given in a dose of 200 mg four times daily. Both drugs provided comparable relief of pain. Side-effects were few and generally mild. The results indicate that in the treatment of osteoarthrosis, floctafenine is comparable to ibuprofen (in the dose used in the study) in terms of efficacy and toxicity.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006057800600103

Reference10 articles.

1. A comparative blood loss study of floctafenine and aspirin in normal subjects [letter].

2. A CONTROLLED TRIAL OF THE ANALGESIC EFFECTS OF FLOCTAFENINE AGAINST PLACEBO IN OSTEOARTHROSIS

3. FLOCTAFENINE: A NEW ANALGESIC FOR USE IN RHEUMATIC DISEASES

4. A comparison of a new analgesic, floctafenine, with dextropropoxyphene and aspirin in post-operative pain

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