Clinical Study on the Efficacy of O-(β-Hydroxyethyl) Rutoside (HR) in Varicosis of Pregnancy

Abstract

In a double-blind trial involving 69 patients, the effect of O-(β-hydroxyethyl) rutoside (HR)* in the treatment of varicosis of pregnancy has been investigated. The number of patients subjectively improving in the active drug group was significantly greater than in the placebo group; patients receiving HR also showed a small but significant decrease in leg circumference. Throughout the eight-week period of the trial, there were only minimal side-effects and healthy babies were delivered with good Apgar-scores.