Immune reconstitution inflammatory syndrome associated with Pneumocystis pneumonia in a patient with AIDS-Reference-Cited by-同舟云学术

Immune reconstitution inflammatory syndrome associated with Pneumocystis pneumonia in a patient with AIDS

Published:2020-08 Issue:8 Volume:48 Page:030006052094654
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Wen Ying¹,Wang Meng-chan²,Zhou Ying¹,Lin Xu-yong³,Hou Gang²^ORCID,Yin Yan²

Affiliation:

1. Department of Infectious Disease, First Hospital of China Medical University, Shenyang, China

2. Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China

3. Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, Shenyang, China

Abstract

Immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment for human immunodeficiency virus (HIV) infection has a wide variety of causes. Delayed diagnosis and treatment of IRIS is fatal. We report a case of a 21-year-old man with HIV infection and Pneumocystis jirovecii pneumonia. The patient presented with fever and dyspnea with deterioration of pulmonary infiltrations 5 days after starting antiretroviral treatment. We reached the diagnosis of IRIS based on radial endobronchial ultrasound (EBUS)-guided lung biopsy. In conclusion, radial EBUS-guided lung biopsy via bronchoscopy is a valuable and minimally invasive technique for the rapid diagnosis of IRIS-associated Pneumocystis jirovecii pneumonia.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0300060520946544

Reference13 articles.

1. Paradoxical Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients Treated With Combination Antiretroviral Therapy After AIDS-Defining Opportunistic Infection

2. Immune reconstitution inflammatory syndrome (IRIS) associated with Cryptococcus neoformans infection in AIDS patients

3. Opportunistic infections and immune reconstitution inflammatory syndrome in HIV-1-infected adults in the combined antiretroviral therapy era: a comprehensive review

4. Anti-CD3 Antibody Decreases Inflammation and Improves Outcome in a Murine Model ofPneumocystisPneumonia

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