Features of antibody responses after SARS-COV-2 infection in healthcare workers in the first wave of COVID-19 pandemic in Mexico City

Author:

Thompson-Bonilla Maria del Rocío1,León Jorge A2,Cárdenas-Turrent Martha Beatriz3,Peña-Thompson Alba1,Hanessian-De la Garza Diana4,Zavala-Vega Sergio5,Xicohtencatl-Cortes Juan6,Ochoa Sara A6,Cruz-Córdova Ariadnna6,Arellano-Galindo José7ORCID

Affiliation:

1. Laboratorio de Medicina Genómica, Hospital Regional “1° de Ocutbre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico

2. Scientific Management of KPC Biotech. California, USA

3. Epidemiología, Hospital Regional “1° de Ocutbre”, ISSSTE, Mexico City, Mexico

4. Medicina Interna, Hospital Regional “1° de Ocutbre”, ISSSTE, Mexico City, Mexico

5. Laboratorio de Neuropatología, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, Mexico City, Mexico

6. Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

7. Unidad de Investigación en Enfermedades Infecciosas, Laboratorio de Virología Clínica y Experimental, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

Abstract

Objective To investigate the antibody response to SARS-CoV-2 and identify associated factors in frontline and second-line healthcare workers (HCWs) at a large hospital in Mexico City during the first wave of COVID-19 pandemic. Methods This was a cross-sectional study of HCWs returning to work following mandatory isolation after recovering from COVID-19. Immunoglobulin (Ig) M and IgG antibodies elicited by SARS-CoV-2 were semiquantitatively measured using densitometric analysis of band intensities in lateral flow assay (LFA) devices. The mean pixel intensity (dots-per-inch [dpi]) of each band on the LFA was considered a measure of antibody titre. Results Of the 111 HCWs involved in the study, antibody responses were detected in 73/111 (66%) participants. Severe COVID symptoms was associated with old age. No differences in IgM intensity were observed between men and women, but IgG intensity was significantly higher in men than in women. Second-line HCWs produced a higher IgG intensity than firstline HCWs. The IgG intensity was high in severe cases. Conclusions For HCWs who may acquire SARS-CoV-2 infection, it is necessary to establish a routine program for detection of the virus to avoid risk of infection and spread of COVID-19.

Funder

KPC-Biotech

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Reference35 articles.

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