Affiliation:
1. Johann A Wülfing, Beecham-Group, Neuss, and Medizinische Klinik III der Städtischen Kliniken Darmstadt, Germany
Abstract
The pharmacokinetic characteristics of ticarcillin, a semisynthetic penicillin more active than carbenicillin against Pseudomonas, were studied. Following a rapid intravenous infusion of 1 g, 2 g, 5 g and 10 g ticarcillin respectively the serum half-life was 72·4 minutes independent of the dosage administered. If ticarcillin is administered under steady-state conditions, e.g. continuous infusion of either 2 g/hr or 1 g/hr following a loading dose of 1 g (total dose 5 g) the average steady-state serum concentrations are 125 μg/ml and 105 μg/ml respectively.
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
8 articles.
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