Urinary Oxalate Recovery after Oral Oxalic Load: An Alternative Method to the Quantitative Determination of Stool Fat for the Diagnosis of Lipid Malabsorption

Author:

Sangaletti O.,Petrillo M.,Porro G. Bianchi1

Affiliation:

1. Gastro-intestinal Unit, L. Sacco Hospital, Milan, Italy

Abstract

Urinary oxalate concentrations were measured in 45 patients with quiescent Crohn's disease, four patients with chronic pancreatitis and five healthy subjects after a normal oxalate (150 g/day) diet, after a high-fat (150 g/day), normal oxalate diet and after a high-oxalate (500 mg/day) diet. Urinary oxalate concentrations were significantly ( P<0.05) higher in patients with Crohn's disease and steatorrhoea, but not in those with chronic pancreatitis, after administrating a high-oxalate diet compared with healthy subjects. Mean oxalate values were 19.1 mg/24 h in controls compared with 65.8 mg/24 h in Crohn's disease patients. A direct correlation ( r=0.37, P<0.01) was established between faecal fats and urinary oxalate after oral oxalate load; this correlation ( r=0.43, P<0.01) is closer when only patients with Crohn's disease are considered. The study, therefore, confirmed a correlation between steatorrhoea and hyperoxaluria in patients with Crohn's disease; however, the high percentage of false positive results limits the use of urinary oxalate concentrations as a reliable indicator of lipid malabsorption. It is concluded that, at present, measurement of urinary oxalate cannot be recommended as a valid alternative to the Van de Kamer method for diagnosing lipid malabsorption.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Nutrition and Gastrointestinal Illness;Present Knowledge in Nutrition;2012-06-18

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