Affiliation:
1. The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
2. Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration Ministry of Education of PRC, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China
Abstract
Objective To assess changes in plasma exosome levels and protein content in mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived exosomes. Exosomal proteins were identified using mass spectrometry. Results Extracellular bodies were successfully isolated from mouse blood. Protein levels were altered in blood-derived exosomes after chronic treadmill exercise. Levels of the secretagogue secretogranin 2 were markedly elevated in exercise-induced exosomes. Conclusion Our data suggest that levels of secretogranin 2 were increased in mouse exosomes following chronic treadmill exercise. We conclude that exercise increases exocrine secretion of secretogranin 2.
Funder
Natural Science Foundation of Guangdong Province
Fundamental Research Funds for the Central Universities to Jinan University
National Natural Science Foundation of China
Project of International as well as Hong Kong, Macao & Taiwan Science and Technology Cooperation Innovation Platform in Universities in Guangdong Province
Program of Introducing Talents of Discipline to Universities
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
13 articles.
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